Nanoparticle preparation of pharmaceutical compounds via wet milling
Alshora et al. prepared pioglitazone HCl (PGZ) nanoparticles via planetary ball milling [65]. They used the Box-Behnken factorial design approach to optimize the number of milling cycles, and the amount of stearic and electrostatic stabilizers. The optimized PGZ nanoparticle formulation enabled the dissolution to reach 100 % in 5 mins.
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